Basic Experimental Pancreatitis Models for Beginners

Basic Experimental Pancreatitis Models for Beginners

Efforts to find an ideal model for pancreatitis date back to 1960’s. Many models are suggested since then. Every model has its own advantages and disadvantages. Some of these models test etiology while others simulate the complications of pancreatitis. An ideal model which by itself demonstrates all aspects of pancreatitis including systemic changes is yet to be described. In this review we tri...

Experimental Models of Pancreatitis

Acute pancreatitis is an inflammatory disease characterized by interstitial edema, inflammatory cell infiltration, and acinar cell necrosis, depending on its severity. Regardless of the extent of tissue injury, acute pancreatitis is a completely reversible process with evident normal tissue architecture after recovery. Its pathogenic mechanism has been known to be closely related to intracellul...

Basic ratio-based DEA models

  In this paper, different input-oriented ratio-based DEA (DEA-R-I) models are proposed. By presenting the envelopment-additive-enhanced Russell model based on the DEA-R-I form, each decision making unit is evaluated and its efficiency score is calculated. Also, by presenting the central resource allocation model based on the DEA-R-I form, a suitable benchmark for all DMUs is proposed by solvin...

Role of S-adenosylmethionine in two experimental models of pancreatitis.

Severe necrotizing pancreatitis occurs in young female mice fed a choline-deficient and ethionine-supplemented (CDE) diet. Although the mechanism of the pancreatitis is unknown, one consequence of this diet is depletion of hepatic S-adenosylmethionine (SAM). SAM formation is catalyzed by methionine adenosyltransferases (MATs), which are encoded by liver-specific (MAT1A) and non-liver-specific (...

Clinical relevance of experimental models of acute pancreatitis